| Speciality |
Short Title |
Full Title |
PI |
NIHR Link (Where available) |
| Anaesthesia |
Epoch |
Enhanced Peri-Operative Care for
High-risk patients (EPOCH) Trial: A stepped wedge randomised
cluster trial of a quality improvement intervention for patients
undergoing emergency laparotomy |
Dr James Limb |
Link |
| - |
The POPULAR Study |
POstanaesthesia PULmonary
complications After use of muscle Relaxants in Europe |
Dr James Limb |
Link |
| Cancer |
ESPAC 4 |
EUROPEAN STUDY GROUP FOR PANCREATIC
CANCER - TRIAL 4. Combination versus single agent chemotherapy in
resectable pancreatic ductal and peri-ampullary cancers. |
Dr Fareeda Coxon |
Link |
| - |
GO2 |
Alternative chemotherapy for frail or
elderly patients with advanced gastric or oesophageal cancer |
Dr Nick Wadd |
Link |
| - |
PERSEPHONE |
Duration of Trastuzumab with
chemotherapy in women with early stage breast cancer: six months
versus twelve |
Dr Wendy Taylor |
Link |
| - |
SELECT-d |
select-d: Anticoagulation Therapy in
SELECTeD Cancer Patients at Risk of Recurrence of Venous
Thromboembolism |
Dr Natalie Cummings |
Link |
| - |
Sofea |
Study of Faslodex with or without
concomitant Arimidex vs Exemestane following progression on
non-steroidal Aromatase inhibitors |
Dr Wendy Taylor |
Link |
| - |
Stampede |
Systemic Therapy in Advancing or
Metastatic Prostate Cancer: Evaluation of Drug Efficacy |
Dr John Hardman |
Link |
| - |
RESPECT-Meso |
A multicentre non-blinded randomised
controlled trial to assess the impact of Regular Early SPEcialist
symptom Control Treatment on quality of life in malignant
Mesothelioma " - RESPECT-Meso" |
Dr Colette Hawkins |
Link |
| - |
MANTA |
A Randomized Phase II Study of
Fulvestrant in Combination with the dual mTOR Inhibitor AZD2014 or
Everolimus or Fulvestrant alone in Estrogen ReceptorPositive
Advanced or Metastatic Breast Cancer |
Dr Wendy Taylor |
Link |
| - |
CAVA |
Cancer and Venous Access (CAVA) - A
randomised controlled trial with associated qualitative research of
venous access devices for the delivery of long-term
chemotherapy |
Dr Julie Cox |
Link |
| Cardiovascular |
REVEAL |
REVEAL: Randomized EValuation of the
Effects of Anacetrapib through Lipid-modification. A large-scale,
randomized placebo-controlled trial of the clinical effects of
anacetrapib among people with established vascular disease |
Dr Jerry Murphy |
Link |
| - |
EMMACE-4 |
Evaluation of the Methods and
Management of Acute Coronary Events-4: Investigating Variation in
Hospital Acute Coronary Syndrome Outcomes |
Dr Mohamed B A El-Harari |
Link |
| - |
LiveLife |
oLder HF patients Initiated on
iVabradinE in the UK: quaLIty of liFE |
Dr Mohamed B A El-Harari |
Link |
| - |
ROSE |
Rivaroxaban Observational Safety
Evaluation (ROSE) Study |
Dr Mohamed B A El-Harari |
Link |
| - |
GLORIA - AF |
GLORIA - AF: Global Registry on
Long-Term Oral Anti-thrombotic TReatment In Patients with Atrial
Fibrillation |
Dr Mohamed B A El-Harari |
Link |
| Children |
PREDNOS |
Long-term tapering verses standard
prednisolone (steroid) therapy for the treatment of the initial
episode of childhood nephrotic syndrome: national multicentre
randomised double blind trial |
Dr John Furness |
Link |
| - |
PREDNOS 2 |
Short course daily prednisolone
therapy at the time of upper respiratory tract infection in
children with relapsing steroid sensitive nephrotic syndrome; the
PREDNOS 2 study. |
Dr Asha Nair |
Link |
| Critical Care |
PROVENT |
Practice of ventilation in critically
ill patients without ARDS (PROVENT). An international observational
study. |
Dr James Limb |
Link |
| DenDrON |
The AMPLE study |
Amyloid imaging for phenotyping Lewy
body dementia |
Dr Mark Carson |
Link |
| - |
Parkinsons Pain |
The Parkinson's Pain Study |
Dr Mark Carson |
Link |
| - |
PD GEN |
PD GENetics: Parkinson's Disease DNA
Bank |
Dr Mark Carson |
Link |
| - |
PRoBaND |
PRoBaND: Parkinson's Repository of
Biosamples and Network Datasets: Prospective observational study of
Parkinson's disease with repeat clinical assessment and biobanking
of blood samples. |
Dr Mark Carson |
Link |
| - |
PROBAND ADD-on |
Assessment of respiratory function in
a representative cohort of patients with early Idiopathic
Parkinson's disease or diagnosed below 50 years of age. Tracking
Parkinson's (PRoBaND) add on study. |
Dr Mark Carson |
Link |
| - |
PD MED |
PD MED: A large randomised assessment
of the relative cost-effectiveness of different classes of drugs
for Parkinson's Disease |
Dr Mark Carson |
Link |
| Dermatology |
SIGNATURE |
Secukinumab in patients with moderate
to severe active, chronic plaque psoriasis who have failed on TNFα
antagonists: a clinical trial evaluating treatment results. |
Dr Shyamal Wahie |
Link |
| - |
Long-term effect of NBUVB on Atopic
Eczema |
Investigating the course of atopic
eczema up to 1 year following completion of Narrowband UVB (NBUVB)
phototherapy |
Dr Shyamal Wahie |
Link |
| - |
AWARE |
AWARE: A Worldwide
Antihistamine Refractory
Chronic Urticaria Patient Evaluation |
Dr Shyamal Wahie |
| - |
Genetics in Acne |
A case-control study for genotype
phenotype associations in moderate to severe acne vulgaris |
Dr Shyamal Wahie |
Link |
| Diabetes |
CAROLINA |
A multicentre, international,
randomised, parallel group, double blind study to evaluate
Cardiovascular safety of linagliptin versus glimepiride in patients
with type 2 diabetes mellitus at high cardiovascular risk. |
Dr Kamal Abouglila |
Link |
| - |
REMOVAL |
REducing with MetfOrmin Vascular
Adverse Lesions in T1DM (The Removal study). |
Dr Kamal Abouglila |
Link |
| - |
INTENSE |
Real World Effectiveness Of
Lixisenatide And Other Intensification Therapy In The Management Of
Type 2 Diabetic Patients Uncontrolled With Basal Insulin |
Dr Kamal Abouglila/Praveen Partha |
Link |
| - |
The CREDENCE Study |
A Randomized, Double-blind,
Event-driven, Placebo-controlled, Multicenter Study of the Effects
of Canagliflozin on Renal and Cardiovascular Outcomes in Subjects
With Type 2 Diabetes Mellitus and Diabetic Nephropathy |
Dr Kamal Abouglila/Praveen Partha |
Link |
| Gastroenterology |
COMPOSE III |
A Randomized Double-blind,
Placebo-controlled,Parallel-group, Multicenter, Phase 3 Study to
Evaluate the Long-term Safety of Naldemedine for the Treatment of
Opioid-induced Constipation in Subjects with Nonmalignant Chronic
Pain Receiving Opioid Therapy |
Dr Yan Yiannakou |
Link |
| - |
ECHO 3 |
A Multicenter, Open-label, Safety and
Tolerability Extension Trial of 5 mg and 10 mg Elobixibat Daily in
the Treatment of Chronic Idiopathic Constipation |
Dr Yan Yiannakou |
Link |
| - |
RAPID |
A randomised placebo controlled trial
of follow on Rifaximin for the prevention of relapse of Clostridium
difficile associated diarrhoea |
Dr Anjan Dhar |
Link |
| - |
seAFOod |
A randomised controlled trial of
eicosapentaenoic acid (EPA) and/or aspirin for colorectal adenoma
(or polyp) prevention during colonoscopic surveillance in the NHS
Bowel Cancer Screening Programme: The seAFOod (Systematic
Evaluation of Aspirin and Fish Oil) polyp prevention trial. |
Clare Westwood |
Link |
| - |
TOPPIC |
Randomised controlled trial of
6-Mercaptopurine versus placebo to prevent recurrence of Crohn's
disease following surgical resection |
Dr Anjan Dhar |
Link |
| - |
CHOPIN |
Chemoprevention of premalignant
intestinal neoplasia (ChOPIN) incorporating inherited
predisposition of neoplasia (IPOD) analysis of genomic DNA from
AspECT and BOSS clinical trials. It also incorporates patients
undergoing genomic assessment independent of the AspECT and BOSS
trials. |
Dr Anjan Dhar |
Link |
| - |
PRED 4 |
Predicting serious drug side effects in
gastroenterology |
Dr Anjan Dhar |
Link |
| - |
PANTS |
Investigation of the clinical,
serological and genetic factors that determine primary
non-response, loss of response and adverse drug reactions to
Anti-TNF drugs in patients with active luminal Crohn's Disease |
Dr Anjan Dhar |
Link |
| - |
TILTS |
Tined lead test stimulation to predict
long-term benefit from sacral nerve stimulation in patients with
chronic constipation (TiLTS-cc). |
Dr Yan Yiannakou |
Link |
| - |
ETHOS |
A pragmatic multicentre randomised
controlled trial comparing stapled haemorrhoidopexy to traditional
excisional surgery for haemorrhoidal disease |
Dr Venkatesh Shanmugam |
Link |
| Haematology |
CELGENE |
A non-interventional post
authorisation registry of patients treated with pomalidomide for
relapsed and refractory multiple myeloma who have received at least
two prior treatment regimens, including both lenalidomide and
bortezomib, and have demonstrated disease progression on the last
therapy
|
Dr Mohsen Mamoud |
Link |
| Hepatology |
PBC Genetics |
Investigation of the Genetic and
Molecular Pathogenesis of Primary Biliary Cirrhosis |
Dr Sushma Saksena |
Link |
| - |
PSC Genetics |
A UK Collaborative Study to Determine
the Genetic Basis of Primary Sclerosing Cholangitis (UK-PSC) |
Dr Sushma Saksena |
Link |
| - |
RITPBC |
Rituximab for the Treatment of Fatigue
in Primary Biliary Cirrhosis (PBC) |
Dr Sushma Saksena |
Link |
| - |
DILIGEN |
Pharmacogenetics of drug-induced liver
injury |
Dr Sushma Saksena |
Link |
| Injuries and Emergencies |
HALT-IT |
Tranexamic Acid for the Treatment of
Gastrointestinal Haemorrhage: An International Randomised, Double
Blind Placebo Controlled Trial |
Dr Ola Afolabi |
Link |
| - |
CRASH 3 |
Tranexamic Acid for the Treatment of
Significant Traumatic Brain Injury: An International, Randomised,
Double Blind, Placebo Controlled Trial. |
Dr Ola Afolabi |
Link |
| Musculoskeletal |
SWITCH |
SWITCH: Randomised-controlled trial of
switching to alternative tumour-necrosis factor (TNF)-blocking
drugs or abatacept or rituximab in patients with rheumatoid
arthritis who have failed an initial TNF-blocking drug |
Dr Dayavathi Ashok |
Link |
| - |
ACT-TAPER |
Randomised, Phase IV,
placebo-controlled, comparative study to evaluate the efficacy and
safety of tapering methotrexate (MTX) dosage versus maintaining the
dosage in patients with severe active rheumatoid arthritis (RA) who
have demonstrated an inadequate response to prior conventional
disease-modifying anti-rheumatic drugs (DMARDs) treatment and have
initiated RoActemra® (tocilizumab, TCZ) in combination with
MTX. |
Dr Matt Bridges |
Link |
| - |
BRAGGSS |
Investigation of factors influencing
arthritis and response to therapy with biologic drugs |
Dr Matt Bridges |
Link |
| - |
BSRBR AS |
British Society for Rheumatology
Biologics Registers - Ankylosing Spondylitis |
Dr Sarah Hailwood |
Link |
| - |
BSRBR |
Prospective observational study of the
long term hazards of biologic therapy in rheumatoid arthritis |
Dr Matt Bridges |
Link |
| - |
TACERA |
The TACERA Study: A Longitudinal
Observational Study of Patients with Early Rheumatoid
Arthritis |
Dr Namita Kumar |
Link |
| - |
FRACTURE FREE |
The Fracture Free Study: A Prospective
Cohort of Patients Presenting with a Fragility Fracture Examining
the Predictors of Re-fracture |
Mr Andrew Jennings |
Link |
| Primary Care |
AFFIRM |
Study to determine the safety and
effectiveness of flutiform®(Affirm) |
Dr John Furness |
Link |
| Reproductive Health and
Childbirth |
Dr Seema Sen |
Link |
| - |
TABLET |
A Randomised Controlled Trial of the
Efficacy and Mechanism of Levothyroxine Treatment on Pregnancy and
Neonatal Outcomes in Women with Thyroid Antibodies. (TABLET:
Thyroid AntiBodies and LEvoThyroxine Study) |
Dr Seema Sen |
Link |
| - |
DAPPA |
Spot protein creatinine ratio (SPCr)
and spot albumin creatinine ratio (SACr) in the assessment of
pre-eclampsia: A diagnostic accuracy study with decision analytic
model based economic evaluation and acceptability analysis |
Dr Seema Sen |
Link |
| - |
FACT |
Effect of folic acid supplementation
in pregnancy on preeclampsia -Folic Acid Clinical Trial (FACT) A
randomized, double-blind, placebo-controlled, Phase III,
international multi-centre study of 4.0 mg of Folic Acid
supplementation in pregnancy for the prevention of
preeclampsia |
Dr Seema Sen |
Link |
| - |
MINESS |
The Midlands and North of England
Stillbirth Study MiNESS |
Dr Seema Sen |
Link |
| - |
EMPIRE |
AntiEpileptic drug Monitoring in
PREgnancy: An evaluation of effectiveness, cost-effectiveness and
acceptability of dose monitoring strategies |
Dr Tadala Saukila |
Link |
| - |
Thyroid Antibody Prevalence Study |
Thyroid Antibody Prevalence Study: A
prospective observational study investigating the prevalence of
thyroid peroxidase antibodies in women of reproductive
age |
Dr Seema Sen |
Link |
| Respiratory Disorders |
Dr Alwyn Foden |
Link |
| - |
RESPECT-Meso |
A multicentre non-blinded randomised
controlled trial to assess the impact of Regular Early SPEcialist
symptom Control Treatment on quality of life in malignant
Mesothelioma " - RESPECT-Meso" |
Dr Colette Hawkins |
Link |
| - |
PASIC |
Pharmacogenetics of Adrenal
Suppression with Inhaled corticosteroids in adults with Chronic
Obstructive Pulmonary Disease |
Dr Neil Munroe |
Link |
| Stroke |
ENCHANTED |
Enhanced Control of Hypertension and
Thrombolysis Stroke Study |
Dr Sofia Dima |
Link |
| - |
FOCUS |
A Multicentre randomised trial to
establish the effect (s) of routine administration of Fluoxetine in
patients with a recent stroke: start-up phase |
Dr Mahesh Dhakal |
Link |
| - |
RESTART |
REstart or STop Antithrombotics
Randomised Trial |
Dr Sofia Dima |
Link |
| - |
TARDIS |
Safety and efficacy of intensive
versus guideline antiplatelet therapy in high risk patients with
recent ischaemic stroke or transient ischaemic attack: a randomised
controlled trial |
Dr David Bruce |
Link |
| - |
TICH 2 |
Tranexamic acid for IntraCerebral
Haemorrhage |
Dr Sofia Dima |
Link |
| Surgery |
VUE |
Vault or Uterine prolapse surgery
Evaluation. Two parallel randomised controlled trials of surgical
options for upper compartment (vauilt or uterine) pelvic organ
prolapse. |
Mr Rob Wood |
Link |
| - |
BASIL 2 |
Multi-centre randomised controlled
trial to compare the clinical and cost-effectiveness of a 'vein
bypass first' with a 'best endovascular first' revascularisation
strategy for severe limb ischaemia due to infra-popliteal arterial
disease: Bypass vs. Angioplasty in Severe Ischaemia of the
Leg. |
Mr Philip Davey |
Link |